Yi-Chen Lai, MD

Critical Care, Texas Children's Hospital / Baylor College of Medicine, Texas Children's Hospital/Baylor College of Medicine

Houston, TX, USA

About

Yi-Chen Lai, MD is an Associate Professor of Pediatrics in the Section of Pediatric Critical Care Medicine at Baylor College of Medicine and Texas Children's Hospital. He completed fellowship and residency at Children's Hospital of Pittsburgh and medical school at University of Pittsburgh.

Research Interests

Pediatric critical careNeurocritical care

Email Website

Publications(21)

Lack of association of first and second-line medication dosing and progression to refractory status epilepticus in children

Barcia Aguilar C, Amengual-Gual M, Brenton JN, Chapman KE, Clark J, Gaillard WD, Goldstein JL, Goodkin HP, Kahoud R, Lai YC, Mikati MA, Morgan LA, Payne ET, Press CA, Reece L, Sands TT, Sannagowdara K, Sheehan T, Shellhaas RA, Tasker RC, Wainwright MS, Zhang B, Loddenkemper T

Seizure (2024) · DOI → · PubMed

Status EpilepticusPharmacology

Intrathecal Dexamethasone as a FIRES Extinguisher: A 12-Patient Clinical Experience with Usage of Intrathecal Dexamethasone for Febrile Infection-Related Epilepsy Syndrome

Farias-Moeller R, Hanin A, Ahsan S, Brooks J, Caganap SD, Czeisler B, Cheuret E, Cocuzzo B, Hahn CD, Kyureghyan H, Marcoux MO, Mohamed R, Park C, Stern Zimmer M, Barun V, Lai YC, Hirsch LJ

Neurocrit Care (2025) · PubMed

NORSE/FIRESStatus EpilepticusPharmacology

The onset of pediatric refractory status epilepticus is not distributed uniformly during the day

Sanchez Fernandez I, Gainza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Davis Gaillard W, Glauser TA, Goldstein J, Goodkin HP, Guerriero RM, Hecox K, Jackson M, Kapur K, Kelley SA, Kossoff EHW, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Stafstrom CE, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Seizure (2019) · DOI → · PubMed

Status Epilepticus

Association of guideline publication and delays to treatment in pediatric status epilepticus

Sánchez Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein J, Goodkin HP, Guerriero RM, Lai YC, McDonough T, Mikati MA, Morgan LA, Novotny E, Payne E, Peariso K, Piantino J, Ostendorf A, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2020) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

First-line medication dosing in pediatric refractory status epilepticus

Vasquez A, Gaínza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Farias-Moeller R, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2020) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkers

Time to Treatment in Pediatric Convulsive Refractory Status Epilepticus: The Weekend Effect

Barcia Aguilar C, Amengual-Gual M, Sánchez Fernández I, Abend NS, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf A, Payne ET, Peariso K, Piantino J, Riviello J, Sannagowdara K, Sheehan T, Sands TT, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T

Pediatr Neurol (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study

Vasquez A, Farias-Moeller R, Sánchez-Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Pediatr Crit Care Med (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Factors associated with long-term outcomes in pediatric refractory status epilepticus

Gaínza-Lein M, Barcia Aguilar C, Piantino J, Chapman KE, Sánchez Fernández I, Amengual-Gual M, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Huh L, Kahoud R, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Nayak A, Novotny E, Ostendorf AP, Payne ET, Peariso K, Reece L, Riviello J, Sannagowdara K, Sands TT, Sheehan T, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T

Epilepsia (2021) · DOI → · PubMed

Status EpilepticusBiomarkersOutcomes

Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus

Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T

Epilepsia (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Implementation of a Pediatric Neurocritical Care Program for Children With Status Epilepticus: Adherence to Continuous Electroencephalogram Monitoring

Herman I, Nguyen T, Chan SW, Erklauer J, Riviello JJ, Lai YC

Pediatr Crit Care Med (2022) · DOI → · PubMed

Neurocritical CareStatus EpilepticusEEG

Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra

Lai YC, Abou-El-Kheir G, Nguyen T, Hanerhoff M, Riviello JJ, Muscal E

Ann Clin Transl Neurol (2023) · DOI → · PubMed

EEGPharmacologyBiomarkersNORSE/FIRES

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children

Peariso K, Arya R, Glauser T, Abend NS, Barcia Aguilar C, Amengual-Gual M, Anderson A, Appavu BL, Brenton JN, Carpenter J, Chapman KE, Clark J, Gaillard WD, Gaínza-Lein M, Goldstein J, Goodkin H, Grinspan Z, Guerriero RM, Horn PS, Huh L, Kahoud R, Kelley SA, Kossoff EH, Kapur K, Lai YC, Marquis BO, McDonough T, Mikati MA, Morgan L, Novotny E, Ostendorf AP, Payne ET, Piantino J, Riviello J, Sands T, Stafstrom CE, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2023) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkers

Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort)

Amengual-Gual M, Sánchez Fernández I, Vasquez A, Abend NS, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Lai YC, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sannagowdara K, Sheehan T, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Seizure (2023) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Fulminant Anti-Myelin Oligodendrocyte Glycoprotein-Associated Cerebral Cortical Encephalitis: Case Series of a Severe Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Phenotype

Kannan V, Sandweiss AJ, Erickson TA, Yarimi JM, Ankar A, Hardwick VA, Shukla NM, Lotze TE, Risen SR, Riviello JJ, Lai YC, Moeller KK, Fisher K

Pediatr Neurol (2023) · DOI → · PubMed

SeizuresOutcomesNeurocritical Care

Introduction to Pediatric Neurocritical Care, 2024

Riviello JJ, Lai YC, Erklauer JC

Semin Pediatr Neurol (2024) · DOI → · PubMed

Neurocritical Care

Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome

Fisher KS, Ankar A, Cokley J, Muscal E, Riviello JJ, Lai YC

Ann Clin Transl Neurol (2025) · DOI → · PubMed

Status EpilepticusPharmacologyNORSE/FIRES

Time to treatment in pediatric patients with repeated episodes of status epilepticus

Gettings JV, Fernández IS, Anderson A, Brenton JN, Can A, Clark J, Moeller RF, Goodkin HP, Lai YC, Mikati MA, Morgan LA, Novotny E, Ostendorf AP, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T, Gaínza-Lein M

BMC Neurol (2025) · DOI → · PubMed

Status EpilepticusEducationPharmacologyBiomarkers

Gastrointestinal symptoms are common in patients with new-onset refractory status epilepticus (NORSE)

Shrestha A, Silveira LJ, Thomas D, Leech J, Lai YC, Riviello JJ, Muscal E, Soden J, Eschbach K

Neurol Sci (2025) · DOI → · PubMed

Status EpilepticusPharmacologyNORSE/FIRES

De novo pathogenic CSF1R variant implicates microglial dysfunction in pathogenesis of febrile infection-related epilepsy syndrome

Fisher KS, Levine JM, Ankar A, Duan R, Lai YC, Muscal E, Risen SR, Riviello JJ, Tsai PC, Calame DG

Epilepsia (2025) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkersNORSE/FIRES

Creating a Robust Community of Practice as a Foundation for the Successful Development of a Pediatric Neurocritical Care Program.

Erklauer JC, Thammasitboon S, Shekerdemian LS, Riviello JJ, Lai YC

Pediatr Neurol (2022) · DOI → · PubMed

Neurocritical CareEducation

Implementation of an Institutional Protocol for the Use of Intrathecal Dexamethasone for Treatment-Refractory Pediatric Neuroinflammatory Disease.

Fisher KS, Muscal E, Lai YC, Riviello JJ, Risen SR, Cokley J

Pediatr Neurol (2025) · DOI → · PubMed

OutcomesEducation