Tobias Loddenkemper, MD

Department of Neurology, Boston Children's Hospital, Boston Children's Hospital

Boston, MA, USA

About

Director of Clinical Epilepsy Research at Boston Children's Hospital and Professor of Neurology at Harvard Medical School. His research focuses on identifying biomarkers and treatment paradigms for epileptic encephalopathies and status epilepticus.

Research Interests

Pediatric EpilepsyClinical NeurophysiologyWearable EEG

Website

Publications(16)

Lack of association of first and second-line medication dosing and progression to refractory status epilepticus in children

Barcia Aguilar C, Amengual-Gual M, Brenton JN, Chapman KE, Clark J, Gaillard WD, Goldstein JL, Goodkin HP, Kahoud R, Lai YC, Mikati MA, Morgan LA, Payne ET, Press CA, Reece L, Sands TT, Sannagowdara K, Sheehan T, Shellhaas RA, Tasker RC, Wainwright MS, Zhang B, Loddenkemper T

Seizure (2024) · DOI → · PubMed

Status EpilepticusPharmacology

Biomarker discovery in Lennox-Gastaut syndrome: Advances and challenges in electrophysiological, genetic, neuroimaging, and neuroinflammatory approaches

Samanta D, Karakas C, Fine AL, Pong AW, Koh HY, Keator C, Loddenkemper T, Mohamed IS, Erdemir G, Dixon-Salazar T, Nascimento FA, Bhatia S, Haridas B, Warren AEL, Patel AD

Epilepsy Behav (2025) · DOI → · PubMed

EpilepsyBiomarkersEEG

Antiseizure medication effects on the autonomic nervous system in pediatric epilepsy

Mohammad Alizadeh Chafjiri F, Dailey S, Sadeghian S, Ulate-Campos A, Loddenkemper T

Epilepsy Res (2025) · DOI → · PubMed

EpilepsyPharmacology

Status epilepticus treatment: multicenter quality improvement

Ostendorf AP, Loddenkemper T, Morgan LA, Appavu B, Farias-Moeller R, Harrar D, Press C, Abend NS, Gaillard WD, Bai S, Eisner M, McHenry L, Kroshus E, Vannatta K, Goodkin HP

Contemp Clin Trials (2025) · PubMed

Status EpilepticusClinical Trial

The onset of pediatric refractory status epilepticus is not distributed uniformly during the day

Sanchez Fernandez I, Gainza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Davis Gaillard W, Glauser TA, Goldstein J, Goodkin HP, Guerriero RM, Hecox K, Jackson M, Kapur K, Kelley SA, Kossoff EHW, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Stafstrom CE, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Seizure (2019) · DOI → · PubMed

Status Epilepticus

Association of guideline publication and delays to treatment in pediatric status epilepticus

Sánchez Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein J, Goodkin HP, Guerriero RM, Lai YC, McDonough T, Mikati MA, Morgan LA, Novotny E, Payne E, Peariso K, Piantino J, Ostendorf A, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2020) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

First-line medication dosing in pediatric refractory status epilepticus

Vasquez A, Gaínza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Farias-Moeller R, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2020) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkers

Time to Treatment in Pediatric Convulsive Refractory Status Epilepticus: The Weekend Effect

Barcia Aguilar C, Amengual-Gual M, Sánchez Fernández I, Abend NS, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf A, Payne ET, Peariso K, Piantino J, Riviello J, Sannagowdara K, Sheehan T, Sands TT, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T

Pediatr Neurol (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study

Vasquez A, Farias-Moeller R, Sánchez-Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Pediatr Crit Care Med (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Factors associated with long-term outcomes in pediatric refractory status epilepticus

Gaínza-Lein M, Barcia Aguilar C, Piantino J, Chapman KE, Sánchez Fernández I, Amengual-Gual M, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Huh L, Kahoud R, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Nayak A, Novotny E, Ostendorf AP, Payne ET, Peariso K, Reece L, Riviello J, Sannagowdara K, Sands TT, Sheehan T, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T

Epilepsia (2021) · DOI → · PubMed

Status EpilepticusBiomarkersOutcomes

Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus

Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T

Epilepsia (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children

Peariso K, Arya R, Glauser T, Abend NS, Barcia Aguilar C, Amengual-Gual M, Anderson A, Appavu BL, Brenton JN, Carpenter J, Chapman KE, Clark J, Gaillard WD, Gaínza-Lein M, Goldstein J, Goodkin H, Grinspan Z, Guerriero RM, Horn PS, Huh L, Kahoud R, Kelley SA, Kossoff EH, Kapur K, Lai YC, Marquis BO, McDonough T, Mikati MA, Morgan L, Novotny E, Ostendorf AP, Payne ET, Piantino J, Riviello J, Sands T, Stafstrom CE, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2023) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkers

Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort)

Amengual-Gual M, Sánchez Fernández I, Vasquez A, Abend NS, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Lai YC, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sannagowdara K, Sheehan T, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Seizure (2023) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Time to treatment in pediatric patients with repeated episodes of status epilepticus

Gettings JV, Fernández IS, Anderson A, Brenton JN, Can A, Clark J, Moeller RF, Goodkin HP, Lai YC, Mikati MA, Morgan LA, Novotny E, Ostendorf AP, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T, Gaínza-Lein M

BMC Neurol (2025) · DOI → · PubMed

Status EpilepticusEducationPharmacologyBiomarkers

Harvard Electroencephalography Database: A comprehensive clinical electroencephalographic resource from four Boston hospitals

Sun C, Jing J, Turley N, Alcott C, Kang WY, Cole AJ, Goldenholz DM, Lam A, Amorim E, Chu C, Cash S, Junior VM, Gupta A, Ghanta M, Nearing B, Nascimento FA, Struck A, Kim J, Sartipi S, Tauton AM, Fernandes M, Sun H, Bayas G, Gallagher K, Wagenaar JB, Sinha N, Lee-Messer C, Silvers CT, Gunapati B, Rosand J, Peters J, Loddenkemper T, Lee JW, Zafar S, Westover MB

Epilepsia (2025) · DOI → · PubMed

Cardiac ArrestEEGMachine LearningEducationEpilepsyPharmacology

Survey of Pediatric ICU EEG Monitoring-Reassessment After a Decade.

Fung FW, Carpenter JL, Chapman KE, Gallentine W, Giza CC, Goldstein JL, Hahn CD, Loddenkemper T, Matsumoto JH, Press CA, Riviello JJ, Abend NS

J Clin Neurophysiol (2023) · DOI → · PubMed

EEGSeizuresEpilepsyStatus EpilepticusNeurocritical Care

Conference Abstracts(3)

Factors Associated with Rapid Treatment for Status Epilepticus: Data from the Quality Improvement in Time to Treat Status Epilepticus (QuiTT-SE) Baseline Cohort

Brown-Mitchell G, Loddenkemper T, Morgan L, Appavu B, Farias-Moeller R, Harrar D, Press C, Abend N, Gaillard W, Bai S, Eisner M, McHenry L, Kroshus E, Vanmatta K, Goodkin H, Ostendorf A

American Epilepsy Society Annual Meeting (2025) · poster

EpilepsyNeurocritical CarePharmacologyStatus Epilepticus

Characteristics and Outcomes of Pediatric Patients with Prolonged Convulsive Status Epilepticus

Gettings J, Eschbach K, Farias-Moeller R, Gaillard W, Glauser T, Goldstein J, Goodkin H, Grinspan Z, Guerriero R, Kahoud R, Loddenkemper T, Novotny E, Morgan L, Ostendorf A, Piantino J, Press CA, Sands T, Tasker R, Kielian A, LaRovere K

American Epilepsy Society Annual Meeting (2024) · poster

EpilepsyNeurocritical CareOutcomesSeizures

Survey of Pediatric ICU EEG Monitoring - Reassessment After a Decade

Fung FW, Carpenter JL, Chapman KE, Gallentine W, Giza CC, Goldstein JL, Hahn CD, Loddenkemper T, Matsumoto JH, Press CA, Riviello JJ Jr, Abend NS

American Clinical Neurophysiology Society Meeting (2023) · poster

EEGNeurocritical CareNeuromonitoring