Matthew Kirschen, MD, PhD, FAAN, FNCS

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia

Philadelphia, PA, USA

About

Pediatric critical care medicine attending physician at Children's Hospital of Philadelphia with expertise in pediatric neurocritical care. Trained in neuroscience (PhD) and medicine at Stanford University, with fellowships in pediatric neurology and critical care at CHOP.

Research Interests

Neurocritical CareCardiac ArrestEEG Monitoring

Website

Publications(17)

Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features

Silva LEV, Chen CC, Press CA, Graham K, Shi L, Abend NS, Morgan RW, Topjian A, Tsui FR, Kirschen MP

Resuscitation (2025) · DOI → · PubMed

Cardiac ArrestMachine LearningqEEG

Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury

Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo AM, Huh JW, Chen SS, Berg RA, Topjian AA, Press CA, Kirschen MP

Res Sq (2025) · DOI → · PubMed

qEEGNeurocritical CareBrain Injury

Practice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest

Kirschen MP, Ullman NL, Reeder RW, Ahmed T, Bell MJ, Berg RA, Burns C, Carcillo JA, Carpenter TC, Wesley Diddle J, Federman M, Fink EL, Frazier AH, Friess SH, Graham K, Horvat CM, Huard LL, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Morgan RW, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Palmer CA, Pollack MM, Sapru A, Sharron MP, Srivastava N, Tilford B, Viteri S, Wolfe HA, Yates AR, Topjian A, Sutton RM, Press CA

Resuscitation (2025) · DOI → · PubMed

Cardiac ArrestNeuroimagingSurvey

Neurocritical Care Entrustable Professional Activities for Pediatric Critical Care Medicine Education and Professional Development

Becker AE, Abend NS, Benedetti GM, Buttram SDW, Chung MG, Erklauer JC, Friess SH, Hong SJ, Huh J, Kirschen MP, LaRovere KL, Lovett ME, Schober ME, Smith KA, Wolfe K, Zurca AD, Topjian AA, Boyer DL

Pediatr Crit Care Med (2025) · PubMed

Neurocritical CareEducation

Neuromonitoring in Pediatric Neurocritical Care: An Introduction

Appavu B, Kirschen MP, Bell M

Neurocrit Care (2024) · DOI → · PubMed

NeuromonitoringNeurocritical CareEditorial

The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up

Brown KL, Agrawal S, Kirschen MP, Traube C, Topjian A, Pressler R, Hahn CD, Scholefield BR, Kanthimathinathan HK, Hoskote A, D'Arco F, Bembea M, Manning JC, Hunfeld M, Buysse C, Tasker RC

Intensive Care Med (2022) · DOI → · PubMed

Neurocritical CareNeuromonitoringReview

Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest

Ullman NL, Reeder RW, Topjian A, Morgan RW, Berg RA, Nadkarni VM, Palmer CA, Sutton RM, Press CA, Kirschen MP

Resuscitation (2025) · DOI → · PubMed

Cardiac ArrestNeuroimaging

A Survey of Neuromonitoring Practices in North American PICUs

Kirschen MP, LaRovere K, Balakrishnan B, Erklauer J, Francoeur C, Ganesan SL, Jayakar A, Lovett M, Luchette M, Press CA, Wolf M, Ferrazzano P, Wainwright MS, Appavu B

Pediatr Neurol (2022) · PubMed

NeuromonitoringSurveyNeurocritical Care

Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices

Piantino JA, Ruzas CM, Press CA, Subramanian S, Balakrishnan B, Panigrahy A, Pettersson D, Maloney JA, Vossough A, Topjian A, Kirschen MP, Doughty L, Chung MG, Maloney D, Haller T, Fabio A, Fink EL

Pediatr Neurol (2022) · DOI → · PubMed

Cardiac ArrestNeuroimagingSurvey

A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care

Erklauer JC, Thomas AX, Hong SJ, Appavu BL, Carpenter JL, Chiriboga-Salazar NR, Ferrazzano PA, Goldstein Z, Griffith JL, Guilliams KP, Kirschen MP, Lidsky K, Lovett ME, McLaughlin B, Munoz Pareja JC, Murphy S, O'Donnell W, Riviello JJ, Schober ME, Topjian AA, Wainwright MS, Simon DW

Children (Basel) (2022) · DOI → · PubMed

Neurocritical CareEducation

Pediatric Moyamoya Revascularization Perioperative Care: A Modified Delphi Study

Sun LR, Jordan LC, Smith ER, Aldana PR, Kirschen MP, Guilliams K, Gupta N, Steinberg GK, Fox C, Harrar DB, Lee S, Chung MG, Dirks P, Dlamini N, Maher CO, Lehman LL, Hong SJ, Strahle JM, Pineda JA, Beslow LA, Rasmussen L, Mailo J, Piatt J, Lang SS, Adelson PD, Dewan MC, Mineyko A, McClugage S, Vadivelu S, Dowling MM, Hersh DS

Neurocrit Care (2023) · DOI → · PubMed

EEGStrokeSurveyOutcomes

Quantitative electroencephalogram in term neonates under different sleep states

Yuan I, Georgostathi G, Zhang B, Hodges A, Kurth CD, Kirschen MP, Huh JW, Topjian AA, Lang SS, Richter A, Abend NS, Massey SL

J Clin Monit Comput (2023) · DOI → · PubMed

qEEGNeonatalSleepPharmacology

Association of EEG Background With Diffusion-Weighted Magnetic Resonance Neuroimaging and Short-Term Outcomes After Pediatric Cardiac Arrest

Bach AM, Kirschen MP, Fung FW, Abend NS, Ampah S, Mondal A, Huh JW, Chen SL, Yuan I, Graham K, Berman JI, Vossough A, Topjian A

Neurology (2024) · DOI → · PubMed

Cardiac ArrestEEGBiomarkersOutcomes

Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury

Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo A, Huh JW, Lang SS, Berg RA, Topjian AA, Press C, Kirschen MP

Neurocrit Care (2026) · DOI → · PubMed

qEEGNeuromonitoringBiomarkersOutcomes

A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care

Children (2022) · DOI → · PubMed

EducationNeurocritical Care

Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process.

Foreman B, Kapinos G, Wainwright MS, Ngwenya LB, O'Phelan KH, LaRovere KL, Kirschen MP, Appavu B, Lazaridis C, Alkhachroum A, Maciel CB, Amorim E, Chang JJ, Gilmore EJ, Rosenthal ES, Park S

Crit Care Med (2023) · DOI → · PubMed

Neurocritical CareTBINeuromonitoringEducation

Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus.

Barrit S, Al Barajraji M, El Hadwe S, Niset A, Foreman B, Park S, Lazaridis C, Shutter L, Appavu B, Kirschen MP, Montellano FA, Rass V, Torcida N, Pinggera D, Gilmore E, Ben-Hamouda N, Massager N, Bernard F, Robba C, Taccone FS

Crit Care (2024) · DOI → · PubMed

Neurocritical Care

Conference Abstracts(3)

Post-Anoxic Myoclonus After Pediatric Cardiac Arrest: Clinical Features, EEG Characteristics, and Outcomes

Bach AM, Walsh KE, Fung FW, Press CA, Kirschen MP, Topjian A, Abend NS

American Epilepsy Society Annual Meeting (2024) · poster

Cardiac ArrestEEGEpilepsyOutcomes

Prognostic Predictions After Pediatric Cardiac Arrest: A Single Center Prospective Study

McSherry M, Zhang B, Louderback L, Little A, Walsh KE, Graham K, Press CA, McGuire J, Ichord R, Douglas R, Morgan RW, Kirschen MP, Woods-Hill C, Topjian A

Resuscitation Science Symposium (2024) · poster

BiomarkersCardiac ArrestOutcomes

Variability of Post-Cardiac Arrest Neuroimaging Practices in Pediatric Intensive Care Units

Ullman NL, Press CA, Palmer CA, Cooper KK, Berg RA, Friess SH, Graham K, Kilbaugh TJ, Morgan R, Mourani PM, Nadkarni VM, Naim MY, Qunibim DW, Reeder RW, Wolfe HA, Sutton RM, Kirschen MP

Neurocritical Care Society Annual Meeting (2021) · poster

Cardiac ArrestNeurocritical Care