Association of hypotension burden calculated from intermittently documented blood pressures and outcome after pediatric cardiac arrest.
Liu R, Nadkarni VM, Berg RA, Morgan RW, Topjian AA, Kirschen MP
Matthew Kirschen, MD, PhD, FAAN, FNCS
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia
Philadelphia, PA, USA
About
Pediatric critical care medicine attending physician at Children's Hospital of Philadelphia with expertise in pediatric neurocritical care. Trained in neuroscience (PhD) and medicine at Stanford University, with fellowships in pediatric neurology and critical care at CHOP.
Research Interests
Neurocritical CareCardiac ArrestEEG Monitoring
Publications(32)
Large language model responses to questions about brain death/death by neurologic criteria: ChatGPT 4o-mini and Gemini 3 Flash (Fast).
Lewis A, Avadhani N, Mehta SD, Hunter RB, Greer D, Kirschen MP
Journal of the neurological sciences (2026) · DOI → · PubMed
A Harmonised Protocol for the Use of PRx in Adult and Paediatric TBI Patients with ICP Monitoring: CLINICCA Workgroup Output.
Beqiri E, Lavinio A, Dias C, Hoedemaekers C, Depreitere B, Helbok R, Weiss M, Schubert G, Kirschen M, Appavu B, Frisvold S, Park S, Smielewski P, Aries M
Neurological Pupil Index and Outcome After Cardiac Arrest in Children: Single-Center, Retrospective Cohort, 2018-2023.
Silver MR, Liu H, Tomlinson AZ, Lacoul A, Graham K, Morgan RW, Traynor D, Kleinschmidt A, Agarwal K, Lourie K, Berg RA, Yehya N, Topjian A, Kirschen MP
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026) · DOI → · PubMed
Individualized Treatment Effects of Therapeutic Hypothermia in Children Postcardiac Arrest: A Reanalysis of Two Randomized Clinical Trials.
Balcarcel DR, Keim GP, Mehta SD, Harhay MO, Himes BE, van Amsterdam WAC, Moler F, Kirschen MP, Topjian AA, Yehya N
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026) · DOI → · PubMed
Pediatric Continuous EEG Monitoring Utilization: An 8-Year Cohort Study Using the Pediatric Health Information System Database.
Fitts W, Press C, Zaniletti I, Benedetti GM, Nash K, Wells EM, Messer R, Palaganas J, Moharir M, Piantino J, Kirschen M, Appavu B, Abend NS
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society (2026) · DOI → · PubMed
Postanoxic Myoclonic Seizures After Pediatric Cardiac Arrest: Characteristics and Outcomes in a Single-Center Cohort, 2018-2024.
Bach AM, Walsh K, Cooper DD, Fung FW, Press CA, Gupta A, Vossough A, Kirschen MP, Topjian AA, Abend NS
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026) · DOI → · PubMed
Correlation of noninvasive near-infrared spectroscopy with outcomes in pediatric traumatic brain injury.
Gabriel ED, Kumar NK, Senthil K, Hejazi-Garcia C, Wang C, Lacoul A, Mazandi V, Wannasarnmetha M, Bhatia A, Tucker AM, Storm PB, Flanders TM, Heuer GG, Kennedy BC, Kirschen M, Topjian A, Francoeur C, Yuan I, Kim CT, Kilbaugh TJ, Huh JW, Lang SS
Transcranial Doppler As Ancillary Testing for Pediatric Brain Death/Death by Neurologic Criteria: Retrospective Study of the Israel Transplant Organ Donor Registry, 2016-2024.
Cohen J, Simon R, Ashkenazi T, Kirschen MP
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026) · DOI → · PubMed
In reply: Hypoxic-ischemic spinal cord injury after cardiac arrest.
Francoeur C, Lehr A, Hornby L, Alkharusi A, Boyd JG, Saint Martin C, Poulin C, Slater F, Kirschen MP, Shemie SD
Canadian journal of anaesthesia = Journal canadien d'anesthesie (2026) · DOI → · PubMed
Real-Time Assessment of Factors Impacting Prognostic Predictions After Pediatric Cardiac Arrest: A Single-Center Prospective Study.
McSherry ML, Zhang B, Louderback L, Little A, Walsh KE, Press CA, McGuire J, Ichord R, Kirschen MP, Woods-Hill C, Topjian A
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026) · DOI → · PubMed
Spinal cord ischemia following pediatric cardiac arrest: An unexplored complication of hypoxic ischemic injury.
Loaec M, Vossough A, Francoeur C, Graham K, Morgan RW, Topjian AA, Kirschen MP
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2026) · DOI → · PubMed
Quality of Bag-Mask Ventilation for Children Before Intubation: Single-Center PICU Pilot Observational Study, 2019-2022.
Shepard LN, Napolitano N, Dominick C, Nickel AJ, Shults J, McGovern EL, Bruins BB, O'Halloran A, Huh J, Topjian A, Kirschen MP, Morgan RW, Sutton RM, Nadkarni VM, Nishisaki A
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026) · DOI → · PubMed
Wolf Creek XVIII Part 8: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award.
Steinberg A, Annoni F, Hayashida K, Hutton J, Kirschen MP, Morgan RW
Machine Learning-Based Return of Spontaneous Circulation Prediction During Cardiopulmonary Resuscitation in a Swine Model of Cardiac Arrest: Effect of Data Resolution and Multimodal Physiological Waveforms.
Silva LEV, Gaudio HA, Padmanabhan V, Forti RM, Shi L, Mason M, Sueishi T, Kirschen MP, Baker WB, Kilbaugh TJ, Morgan RW, Tsui FR, Ko TS
Prediction of neurological outcome after pediatric cardiac arrest using heart rate variability and machine learning.
Silva LEV, Balcarcel D, Ko TS, Morgan RW, Berg RA, Topjian A, Tsui FR, Kirschen MP
Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury
Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo A, Huh JW, Lang SS, Berg RA, Topjian AA, Press C, Kirschen MP
Neurocrit Care (2026) · DOI → · PubMed
qEEGNeuromonitoringBiomarkersOutcomes
Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest
Ullman NL, Reeder RW, Topjian A, Morgan RW, Berg RA, Nadkarni VM, Palmer CA, Sutton RM, Press CA, Kirschen MP
Resuscitation (2025) · DOI → · PubMed
Cardiac ArrestNeuroimaging
Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features
Silva LEV, Chen CC, Press CA, Graham K, Shi L, Abend NS, Morgan RW, Topjian A, Tsui FR, Kirschen MP
Resuscitation (2025) · DOI → · PubMed
Cardiac ArrestMachine LearningqEEG
Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury
Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo AM, Huh JW, Chen SS, Berg RA, Topjian AA, Press CA, Kirschen MP
Res Sq (2025) · DOI → · PubMed
qEEGNeurocritical CareBrain Injury
Practice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest
Kirschen MP, Ullman NL, Reeder RW, Ahmed T, Bell MJ, Berg RA, Burns C, Carcillo JA, Carpenter TC, Wesley Diddle J, Federman M, Fink EL, Frazier AH, Friess SH, Graham K, Horvat CM, Huard LL, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Morgan RW, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Palmer CA, Pollack MM, Sapru A, Sharron MP, Srivastava N, Tilford B, Viteri S, Wolfe HA, Yates AR, Topjian A, Sutton RM, Press CA
Resuscitation (2025) · DOI → · PubMed
Cardiac ArrestNeuroimagingSurvey
Neurocritical Care Entrustable Professional Activities for Pediatric Critical Care Medicine Education and Professional Development
Becker AE, Abend NS, Benedetti GM, Buttram SDW, Chung MG, Erklauer JC, Friess SH, Hong SJ, Huh J, Kirschen MP, LaRovere KL, Lovett ME, Schober ME, Smith KA, Wolfe K, Zurca AD, Topjian AA, Boyer DL
Pediatr Crit Care Med (2025) · PubMed
Neurocritical CareEducation
Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus.
Barrit S, Al Barajraji M, El Hadwe S, Niset A, Foreman B, Park S, Lazaridis C, Shutter L, Appavu B, Kirschen MP, Montellano FA, Rass V, Torcida N, Pinggera D, Gilmore E, Ben-Hamouda N, Massager N, Bernard F, Robba C, Taccone FS
Crit Care (2024) · DOI → · PubMed
Neurocritical Care
Association of EEG Background With Diffusion-Weighted Magnetic Resonance Neuroimaging and Short-Term Outcomes After Pediatric Cardiac Arrest
Bach AM, Kirschen MP, Fung FW, Abend NS, Ampah S, Mondal A, Huh JW, Chen SL, Yuan I, Graham K, Berman JI, Vossough A, Topjian A
Neurology (2024) · DOI → · PubMed
Cardiac ArrestEEGBiomarkersOutcomes
Neuromonitoring in Pediatric Neurocritical Care: An Introduction
Appavu B, Kirschen MP, Bell M
Neurocrit Care (2024) · DOI → · PubMed
NeuromonitoringNeurocritical CareEditorial
Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process.
Foreman B, Kapinos G, Wainwright MS, Ngwenya LB, O'Phelan KH, LaRovere KL, Kirschen MP, Appavu B, Lazaridis C, Alkhachroum A, Maciel CB, Amorim E, Chang JJ, Gilmore EJ, Rosenthal ES, Park S
Crit Care Med (2023) · DOI → · PubMed
Neurocritical CareTBINeuromonitoringEducation
Quantitative electroencephalogram in term neonates under different sleep states
Yuan I, Georgostathi G, Zhang B, Hodges A, Kurth CD, Kirschen MP, Huh JW, Topjian AA, Lang SS, Richter A, Abend NS, Massey SL
J Clin Monit Comput (2023) · DOI → · PubMed
qEEGNeonatalSleepPharmacology
Pediatric Moyamoya Revascularization Perioperative Care: A Modified Delphi Study
Sun LR, Jordan LC, Smith ER, Aldana PR, Kirschen MP, Guilliams K, Gupta N, Steinberg GK, Fox C, Harrar DB, Lee S, Chung MG, Dirks P, Dlamini N, Maher CO, Lehman LL, Hong SJ, Strahle JM, Pineda JA, Beslow LA, Rasmussen L, Mailo J, Piatt J, Lang SS, Adelson PD, Dewan MC, Mineyko A, McClugage S, Vadivelu S, Dowling MM, Hersh DS
Neurocrit Care (2023) · DOI → · PubMed
EEGStrokeSurveyOutcomes
A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care
Erklauer JC, Thomas AX, Hong SJ, Appavu BL, Carpenter JL, Chiriboga-Salazar NR, Ferrazzano PA, Goldstein Z, Griffith JL, Guilliams KP, Kirschen MP, Lidsky K, Lovett ME, McLaughlin B, Munoz Pareja JC, Murphy S, O'Donnell W, Riviello JJ, Schober ME, Topjian AA, Wainwright MS, Simon DW
Children (Basel) (2022) · DOI → · PubMed
Neurocritical CareEducation
Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices
Piantino JA, Ruzas CM, Press CA, Subramanian S, Balakrishnan B, Panigrahy A, Pettersson D, Maloney JA, Vossough A, Topjian A, Kirschen MP, Doughty L, Chung MG, Maloney D, Haller T, Fabio A, Fink EL
Pediatr Neurol (2022) · DOI → · PubMed
Cardiac ArrestNeuroimagingSurvey
The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up
Brown KL, Agrawal S, Kirschen MP, Traube C, Topjian A, Pressler R, Hahn CD, Scholefield BR, Kanthimathinathan HK, Hoskote A, D'Arco F, Bembea M, Manning JC, Hunfeld M, Buysse C, Tasker RC
Intensive Care Med (2022) · DOI → · PubMed
Neurocritical CareNeuromonitoringReview
A Survey of Neuromonitoring Practices in North American PICUs
Kirschen MP, LaRovere K, Balakrishnan B, Erklauer J, Francoeur C, Ganesan SL, Jayakar A, Lovett M, Luchette M, Press CA, Wolf M, Ferrazzano P, Wainwright MS, Appavu B
Pediatr Neurol (2022) · PubMed
NeuromonitoringSurveyNeurocritical Care
Conference Abstracts(3)
Post-Anoxic Myoclonus After Pediatric Cardiac Arrest: Clinical Features, EEG Characteristics, and Outcomes
Bach AM, Walsh KE, Fung FW, Press CA, Kirschen MP, Topjian A, Abend NS
American Epilepsy Society Annual Meeting (2024) · poster
Cardiac ArrestEEGEpilepsyOutcomes
Prognostic Predictions After Pediatric Cardiac Arrest: A Single Center Prospective Study
McSherry M, Zhang B, Louderback L, Little A, Walsh KE, Graham K, Press CA, McGuire J, Ichord R, Douglas R, Morgan RW, Kirschen MP, Woods-Hill C, Topjian A
Resuscitation Science Symposium (2024) · poster
BiomarkersCardiac ArrestOutcomes
Variability of Post-Cardiac Arrest Neuroimaging Practices in Pediatric Intensive Care Units
Ullman NL, Press CA, Palmer CA, Cooper KK, Berg RA, Friess SH, Graham K, Kilbaugh TJ, Morgan R, Mourani PM, Nadkarni VM, Naim MY, Qunibim DW, Reeder RW, Wolfe HA, Sutton RM, Kirschen MP
Neurocritical Care Society Annual Meeting (2021) · poster
Cardiac ArrestNeurocritical Care