Mark Wainwright, MD, PhD

Neurology, University of Washington / Seattle Children's

Seattle, WA, USA

About

Division Chief of Neurology and Director of the Neurocritical Care Program at Seattle Children's Hospital and Professor of Neurology at the University of Washington. His research focuses on brain monitoring and recovery after pediatric cardiac arrest, stroke, and status epilepticus.

Research Interests

Pediatric Neurocritical CareCardiac ArrestRefractory Status EpilepticusStrokeTraumatic Brain InjuryNon-invasive Neuromonitoring

Email Website

Publications(29)

Acute and Long-Term EEG and seizure characteristics in new onset refractory status epilepticus (NORSE).

Gilani K, Hanin A, Gaspard N, Batra A, Behrndt L, Day GS, Demeret S, Eschbach K, Foreman B, Gerard EE, Gofton TE, Gopaul MT, Haider HA, Hantus ST, Cobos-Hernandez C, Jimenez AD, Jongeling A, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Farias-Moeller R, Morales M, Navarro V, Pimentel CM, Ramirez A, Steriade C, Struck AF, Taraschenko O, Wainwright MS, Zhou DJ, Hirsch LJ, Yoo JY

Epilepsia (2026) · DOI → · PubMed

Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus.

Meletti S, Hanin A, Giovannini G, Bedin R, Burani M, Taruffi L, Orlandi N, Urbano T, D'Achille F, Malerba M, Basha MM, Eschbach K, Foreman B, Farias-Moeller R, Gaspard N, Gerard EE, Gofton T, Gopaul MT, Haider HA, Hantus ST, Herman S, Kang P, Day GS, Kandula P, Steriade C, Struck AF, Taraschenko O, Wainwright M, Yoo JY, Zhou DJ, Lattanzi S, Navarro V, Hirsch LJ

JAMA neurology (2026) · DOI → · PubMed

Exploring pathways leading to drug-resistant epilepsy for patients with cryptogenic new onset refractory status epilepticus

Hanin A, Marois C, Guillemaud M, Chavez M, Cosme L, Hayatou Z, Besnard A, Goudard G, Masson V, Cousyn L, Cheval M, Denis JA, Alkouri R, Lamari F, Bisulli F, Eschbach K, Farias-Moeller R, Gaspard N, Gerard EE, Giovannini G, Gofton T, Gopaul MT, Kellogg M, Meletti S, Muccioli L, Pasini E, Taraschenko O, Torcida N, Wainwright MS, Yoo JY, Wong N, Bonnefont-Rousselot D, Demeret S, Hirsch LJ, Navarro V

Epilepsia (2026) · DOI → · PubMed

NORSE/FIRESEpilepsyStatus Epilepticus

Predicting pediatric cardiac arrest outcomes using early quantitative EEG

Benedetti GM, Pardo AC, Nelson Sanchez-Pinto L, Straley M, Wainwright MS, Kurz JE, Press CA

Resuscitation (2025) · DOI → · PubMed

Cardiac ArrestqEEGMachine Learning

Time to treatment in pediatric patients with repeated episodes of status epilepticus

Gettings JV, Fernández IS, Anderson A, Brenton JN, Can A, Clark J, Moeller RF, Goodkin HP, Lai YC, Mikati MA, Morgan LA, Novotny E, Ostendorf AP, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T, Gaínza-Lein M

BMC Neurol (2025) · DOI → · PubMed

Status EpilepticusEducationPharmacologyBiomarkers

Lack of association of first and second-line medication dosing and progression to refractory status epilepticus in children

Barcia Aguilar C, Amengual-Gual M, Brenton JN, Chapman KE, Clark J, Gaillard WD, Goldstein JL, Goodkin HP, Kahoud R, Lai YC, Mikati MA, Morgan LA, Payne ET, Press CA, Reece L, Sands TT, Sannagowdara K, Sheehan T, Shellhaas RA, Tasker RC, Wainwright MS, Zhang B, Loddenkemper T

Seizure (2024) · DOI → · PubMed

Status EpilepticusPharmacology

Corrigendum: Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C.

Fink EL, Alcamo AM, Lovett M, Hartman M, Williams C, Garcia A, Rasmussen L, Pal R, Drury K, MackDiaz E, Ferrazzano PA, Dervan L, Appavu B, Snooks K, Stulce C, Rubin P, Pate B, Toney N, Robertson CL, Wainwright MS, Roa JD, Schober ME, Slomine BS

Front Pediatr (2024) · DOI → · PubMed

COVID-19Outcomes

Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C.

Front Pediatr (2024) · DOI → · PubMed

Neurocritical CareCOVID-19Outcomes

Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and 1-Year Outcomes

Francoeur C, Alcamo AM, Robertson CL, Wainwright MS, Appavu B

JAMA Netw Open (2024) · PubMed

COVID-19Neurocritical Care

Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process.

Foreman B, Kapinos G, Wainwright MS, Ngwenya LB, O'Phelan KH, LaRovere KL, Kirschen MP, Appavu B, Lazaridis C, Alkhachroum A, Maciel CB, Amorim E, Chang JJ, Gilmore EJ, Rosenthal ES, Park S

Crit Care Med (2023) · DOI → · PubMed

Neurocritical CareTBINeuromonitoringEducation

Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort)

Amengual-Gual M, Sánchez Fernández I, Vasquez A, Abend NS, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Lai YC, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sannagowdara K, Sheehan T, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Seizure (2023) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children

Peariso K, Arya R, Glauser T, Abend NS, Barcia Aguilar C, Amengual-Gual M, Anderson A, Appavu BL, Brenton JN, Carpenter J, Chapman KE, Clark J, Gaillard WD, Gaínza-Lein M, Goldstein J, Goodkin H, Grinspan Z, Guerriero RM, Horn PS, Huh L, Kahoud R, Kelley SA, Kossoff EH, Kapur K, Lai YC, Marquis BO, McDonough T, Mikati MA, Morgan L, Novotny E, Ostendorf AP, Payne ET, Piantino J, Riviello J, Sands T, Stafstrom CE, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2023) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkers

Safety of intravenous lacosamide in hospitalized children and neonates

Fong SL, Utidjian L, Kaur M, Abend NS, Wainwright MS, Grande KM, Foskett N, Roebling R, Guerriero RM, Jain B, Rao S, Stoltenberg M, Williams P, Yuen N, Dickinson K, McDonald J, Maltenfort M, Forrest CB

Epilepsia (2023) · DOI → · PubMed

Cardiac ArrestNeonatalSeizuresPharmacology

A Survey of Pediatric Neurocritical Care Fellowship Training in North America

Hong SJ, Wainwright MS, Abend NS, Appavu BL, Francoeur C, Erklauer JC, Guerguerian AM, Guerriero RM, Guilliams KP, Lee-Eng J, Loeb J, Lovett ME, Murphy SA, Pardo AC, Pineda JA, Ruzas CM, Topjian AA

Pediatr Neurol (2023) · DOI → · PubMed

Neurocritical CareEEGSurveyEducation

The Spectrum of Quantitative EEG Utilization Across North America: A Cross-Sectional Survey

Benedetti GM, Morgan LA, Sansevere AJ, Harrar DB, Guerriero RM, Wainwright MS, LaRovere KL, Kielian A, Ganesan SL, Press CA

Pediatr Neurol (2023) · PubMed

qEEGSurveyNeuromonitoring

A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care

Erklauer JC, Thomas AX, Hong SJ, Appavu BL, Carpenter JL, Chiriboga-Salazar NR, Ferrazzano PA, Goldstein Z, Griffith JL, Guilliams KP, Kirschen MP, Lidsky K, Lovett ME, McLaughlin B, Munoz Pareja JC, Murphy S, O'Donnell W, Riviello JJ, Schober ME, Topjian AA, Wainwright MS, Simon DW

Children (Basel) (2022) · DOI → · PubMed

Neurocritical CareEducation

Pediatric Critical Care Neurologists in the United States and Canada: A Survey of Clinical Practice Experience

Farias-Moeller R, Jayakar A, Guerriero RM, Carpenter JL, Wainwright MS, Harrar DB

J Child Neurol (2022) · DOI → · PubMed

Neurocritical CareSurveyEducation

A Survey of Neuromonitoring Practices in North American PICUs

Kirschen MP, LaRovere K, Balakrishnan B, Erklauer J, Francoeur C, Ganesan SL, Jayakar A, Lovett M, Luchette M, Press CA, Wolf M, Ferrazzano P, Wainwright MS, Appavu B

Pediatr Neurol (2022) · PubMed

NeuromonitoringSurveyNeurocritical Care

Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C.

Fink EL, Robertson CL, Wainwright MS, Roa JD, Lovett ME, Stulce C, Yacoub M, Potera RM, Zivick E, Holloway A, Nagpal A, Wellnitz K, Czech T, Even KM, Brunow de Carvalho W, Rodriguez IS, Schwartz SP, Walker TC, Campos-Mino S, Dervan LA, Geneslaw AS, Sewell TB, Pryce P, Silver WG, Lin JE, Vargas WS, Topjian A, Alcamo AM, McGuire JL, Dominguez Rojas JA, Munoz JT, Hong SJ, Muller WJ, Doerfler M, Williams CN, Drury K, Bhagat D, Nelson A, Price D, Dapul H, Santos L, Kahoud R, Francoeur C, Appavu B, Guilliams KP, Agner SC, Walson KH, Rasmussen L, Janas A, Ferrazzano P, Farias-Moeller R, Snooks KC, Chang CH, Yun J, Schober ME

Pediatr Neurol (2021) · DOI → · PubMed

COVID-19

Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study

Vasquez A, Farias-Moeller R, Sánchez-Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Pediatr Crit Care Med (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus

Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T

Epilepsia (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

Factors associated with long-term outcomes in pediatric refractory status epilepticus

Gaínza-Lein M, Barcia Aguilar C, Piantino J, Chapman KE, Sánchez Fernández I, Amengual-Gual M, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Huh L, Kahoud R, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Nayak A, Novotny E, Ostendorf AP, Payne ET, Peariso K, Reece L, Riviello J, Sannagowdara K, Sands TT, Sheehan T, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T

Epilepsia (2021) · DOI → · PubMed

Status EpilepticusBiomarkersOutcomes

Time to Treatment in Pediatric Convulsive Refractory Status Epilepticus: The Weekend Effect

Barcia Aguilar C, Amengual-Gual M, Sánchez Fernández I, Abend NS, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf A, Payne ET, Peariso K, Piantino J, Riviello J, Sannagowdara K, Sheehan T, Sands TT, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T

Pediatr Neurol (2021) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

First-line medication dosing in pediatric refractory status epilepticus

Vasquez A, Gaínza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman K, Clark J, Farias-Moeller R, Gaillard WD, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2020) · DOI → · PubMed

Status EpilepticusPharmacologyBiomarkers

Association of guideline publication and delays to treatment in pediatric status epilepticus

Sánchez Fernández I, Abend NS, Amengual-Gual M, Anderson A, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein J, Goodkin HP, Guerriero RM, Lai YC, McDonough T, Mikati MA, Morgan LA, Novotny E, Payne E, Peariso K, Piantino J, Ostendorf A, Sands TT, Sannagowdara K, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Neurology (2020) · DOI → · PubMed

Status EpilepticusPharmacologyOutcomes

The onset of pediatric refractory status epilepticus is not distributed uniformly during the day

Sanchez Fernandez I, Gainza-Lein M, Abend NS, Amengual-Gual M, Anderson A, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Davis Gaillard W, Glauser TA, Goldstein J, Goodkin HP, Guerriero RM, Hecox K, Jackson M, Kapur K, Kelley SA, Kossoff EHW, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Riviello JJ, Sannagowdara K, Stafstrom CE, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T

Seizure (2019) · DOI → · PubMed

Status Epilepticus

Early Presence of Sleep Spindles on Electroencephalography Is Associated With Good Outcome After Pediatric Cardiac Arrest

Ducharme-Crevier L, Press CA, Kurz JE, Mills MG, Goldstein JL, Wainwright MS

Pediatr Crit Care Med (2017) · DOI → · PubMed

EEGCardiac ArrestSleep

Spectral Electroencephalogram Analysis for the Evaluation of Encephalopathy Grade in Children With Acute Liver Failure

Press CA, Morgan L, Mills M, Stack CV, Goldstein JL, Alonso EM, Wainwright MS

Pediatr Crit Care Med (2017) · DOI → · PubMed

qEEGCardiac ArrestNeurocritical Care

Preventable Pediatric Stroke via Vaccination?

Press CA, Wainwright MS

Pediatr Neurol Briefs (2015) · DOI → · PubMed

Stroke

Conference Abstracts(8)

Early Non-Dichotomous Quantitative EEG Variables Predict Long-Term Outcomes After Pediatric Cardiac Arrest

Benedetti GM, Straley M, Pardo AC, Sanchez-Pinto LN, Wainwright MS, Kurz JE, Press CA

American Epilepsy Society Annual Meeting (2022) · poster

Cardiac ArrestEEGEpilepsyOutcomesqEEG

Predictive Value of Quantitative EEG 24-Hours After Pediatric Cardiac Arrest

Benedetti GM, Straley M, Pardo AC, Sanchez-Pinto LN, Wainwright MS, Kurz JE, Press CA

Neurocritical Care Society Annual Meeting (2022) · oral

Cardiac ArrestEEGNeurocritical CareOutcomesqEEG

Trends in Quantitative EEG Use in Pediatric Critical Care Across North America

Benedetti GM, Morgan LA, Sansevere AJ, Harrar DB, Guerriero RM, Wainwright MS, LaRovere KL, Kielian A, Lalgudi Ganesan S, Press CA

Child Neurology Society Annual Meeting (2022) · poster

EEGNeurocritical CareqEEG

Heart Rate Variability and EEG Characteristics in Children with CAR T-Associated Neurotoxicity

Dervan LA, Doud A, Di Gennaro JL, Benedetti GM, Morgan LA, Amlie-Lefond C, Watson RS, Wainwright M

Society of Critical Care Medicine Annual Meeting (2022) · poster

EEGNeurocritical Care

Neuromonitoring Practice is Highly Variable in Pediatric Extracorporeal Membrane Oxygenation

Ruzas CM, Benedetti GM, Kurz J, Press CA, Kim J, Daniels Z, Smith C, Wainwright MS

Neurocritical Care Society Annual Meeting (2021) · poster

ECMO/ECLSNeurocritical CareNeuromonitoring

Early Quantitative Electroencephalogram Measurements Correlate with Outcome in Pediatric Cardiac Arrest

Benedetti GM, Wainwright MS, Din F, Kurz JE

Child Neurology Society Annual Meeting (2018) · oral

Cardiac ArrestEEGOutcomesqEEG

Variation in Treatment and Outcomes of Children With Acute Disseminated Encephalomyelitis

Press CA, Kirschen M, LaRovere K, Risen S, Guilliams K, Chung M, Griffith J, Erklauer J, Peariso K, Ducharme-Crevier L, Shah S, Hall M, Wainwright M

American Academy of Neurology Annual Meeting (2018) · poster

OutcomesPharmacology

Use of PHIS Database for Outcomes Studies: A Proposed PNCRG Workgroup

Press CA, Wainwright MS

Pediatric Neurocritical Care Research Group (2016) · invited

Neurocritical CareOutcomes